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Absence of Enhancing Antibody in Cell Mediated Immunity to Tumour Heterografts in Protein Deficient Rats

Abstract

THE classical association between famine and pestilence reflects the decrease in host resistance to bacterial infection occurring in malnutrition1. Little is known, however, about the influence of malnutrition on cell-mediated immunity2. A marked decrease in incidence and growth of spontaneous and transplanted malignancies in animals fed restricted diets, first reported by Moreschi3 and Rous4, has been confirmed for many tumour types in rodents5–7 and cattle8 and with restriction of either caloric9 or protein intake10. Malnutrition increases resistance to virus infections in man11.

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JOSE, D., GOOD, R. Absence of Enhancing Antibody in Cell Mediated Immunity to Tumour Heterografts in Protein Deficient Rats. Nature 231, 323–325 (1971). https://doi.org/10.1038/231323b0

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