MIGRAINE afflicts some 10–15% of the population, which includes a subgroup of dietary migraine sufferers, all of whom specifically exclude certain foods from their diet. When Hanington1 studied this group extensively all subjects reacted adversely to chemically pure tyramine. Indeed, an oral dose of 100 mg of the pure chemical precipitated a migraine attack entirely indistinguishable from the classic migraine of the subjects concerned1,2. Because of this significant correlation, we decided to investigate the metabolism of tyramine in normal and dietary migraine subjects using large doses of tyramine and, separately, tracer doses of 14C-tyramine.
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Hanington, E., in Background to Migraine, Second Migraine Symp. (edit. by Smith, R.) (Heinemann, London, 1967).
Smith, I., Kellow, A. H., and Hanington, E., in Background to Migraine, Third Migraine Symp. (edit. by Cochrane, A. L.), 134 (Heinemann, London, 1970).
Oates, J. A., in Methods of Medical Research (edit. by Quastel, J. H.), 9, 169 (Year Book Medical Publications, Chicago, 1961).
Karoum, F., Ruthven, C. R. J., and Sandler, M., Clin. Chim. Acta, 20, 427 (1968).
Lemberger, L., Klutch, A., and Kuntzmann, R., J. Pharmacol. Exp. Ther., 153, 183 (1966).
Häggendal, J., Acta Physiol. Scand., 59, 255 (1963).
Morgan, C. D., Ruthven, C. R. J., and Sandler, M., Clin. Chim. Acta, 26, 381 (1969).
LaBrosse, E. H., and Mann, J. D., Nature, 185, 40 (1960).
Axelrod, J., Kopin, I. J., and Mann, J. D., Biochim. Biophys. Acta, 36, 576 (1959).
Goodall, McC., and Alton, H., Biochem. Pharmacol., 17, 905 (1968).
Davis, V. E., and Walsh, M. J., Science, 167, 1005 (1970).
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SMITH, I., KELLOW, A., MULLEN, P. et al. Dietary Migraine and Tyramine Metabolism. Nature 230, 246–248 (1971). https://doi.org/10.1038/230246a0
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