Abstract
RUBIDIUM, when introduced intravenously, behaves similarly to potassium, being incorporated principally within the intracellular pool1,2. The radionuclide 81Rb (refs. 3–5), produced in a cyclotron, decays with a half life of 4 h 34 min to 81mKr, which in turn decays with a half life of 13 s to stable 81Kr. Therefore the amount of 81Rb within a tissue after administration changes only slowly1, whereas its daughter, being inert, mixes uniformly with the tissue6 and is removed from it at a rate dependent on the perfusion of the tissue. At equilibrium the ratio of 81mKr to 81Rb within a tissue is given by: λ1/(λ2+ K), where λ1 and λ2 are the disintegration rate constants of 81Rb and 81mKr respectively and K the perfusion rate constant of the tissue. Thus the relationship between 81Rb and its inert gas daughter could provide a unique method for measuring tissue perfusion.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kilpatrick, C., Renschler, H. E., Munro, D. S., and Wilson, G. M., J. Physiol., 133, 194 (1956).
Burch, G. E., Threefoot, S. A., and Ray, C. T., J. Lab. Clin. Med., 45, 371 (1955).
Jones, T., Clark, J. C., Hughes, J. M., and Rosenzweig, D. Y., J. Nuclear Med., 11, No. 3, 118 (1970).
Watson, I. A., Radiochem. Radioanal. Lett., 4, No. 1 (1970).
Watson, I. A., and Tilbury, R. S., J. Nuclear Med., 11, No. 6, 373 (1970).
Kety, S. S., Pharmacol. Rev., 3, 1 (1951).
Saperstein, L. A., Amer. J. Physiol., 193, 161 (1958).
Donato, L., Bartolomei, G., Federighi, G., and Torrengiani, G., Circulation, 33, 708 (1966).
Zierler, K. L., Circulation Res., 16, 309 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JONES, T., MATTHEWS, C. Tissue Perfusion measured using the Ratio of 81Rb to 81mKr incorporated in the Tissue. Nature 230, 119–120 (1971). https://doi.org/10.1038/230119a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/230119a0
This article is cited by
-
Preparation of Chitosan microspheres containing 166Dy/166Ho in vivo generators and their theranostic potential
Journal of Radioanalytical and Nuclear Chemistry (2018)
-
Myocardial perfusion measured by dual-isotope acquisition of81rubidium/81mkrypton: an experimental verification of the method
Basic Research in Cardiology (1994)
-
Cyclotron production of radioisotopes for use in nuclear medicine
Journal of Radioanalytical Chemistry (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.