Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lentinan, a New Immuno-accelerator of Cell-mediated Responses

Abstract

BCG is almost the only agent now used as the immuno-accelerator of cell-mediated responses1'3, but it has various biological side effects and a complicated chemical structure, so that it is not necessarily the most suitable agent. We reported that lentinan4,5 and pachymaran6 strongly inhibited the growth of transplanted tumours in mice, and these two polysaccharides are worth considering as excellent immuno-accelerators.

References

  1. 1

    Biozzi, G., Stiffel, C., Halpern, B. N., and Mouton, D., CR Soc. Biol., 153, 987 (1959).

    CAS  Google Scholar 

  2. 2

    Old, L. J., Clarke, D. A., and Benacerraf, B., Nature, 184, 291 (1959).

    ADS  Article  Google Scholar 

  3. 3

    Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E. A., and Stokert, E., Cancer Res., 21, 1281 (1961).

    CAS  PubMed  Google Scholar 

  4. 4

    Chihara, G., Maeda, Y. Y., Hamuro, J., Sasaki, T., and Fukuoka, F., Nature, 222, 687 (1969).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Chihara, G., Hamuro, J., Maeda, Y. Y., Arai, Y., and Fukuoka, F., Cancer Res. (in the press).

  6. 6

    Chihara, G., Hamuro, J., Maeda, Y. Y., Arai, Y., and Fukuoka, F., Nature, 225, 943 (1970).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Sjodin, K., Dalmasso, A. P., Smith, J. M., and Martinez, C., Transplantation, 1, 521 (1963).

    CAS  Article  Google Scholar 

  8. 8

    Gray, J. G., Monaco, A. P., Wood, M. L., and Russell, P. S., J. Immunol., 96, 217 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. 9

    Levey, R. H., and Medawar, P. B., Antilymphocytic Serum Ciba Found. Study Group, 29, 72 (1967).

    Google Scholar 

  10. 10

    Levey, R. H., Fed. Proc., 29, 156 (1970).

    CAS  PubMed  Google Scholar 

  11. 11

    Lance, E. M., and Batchelor, J. R., Transplantation, 6, 490 (1968).

    CAS  Article  Google Scholar 

  12. 12

    Lance, E. M., Fed. Proc., 29, 209 (1970).

    CAS  PubMed  Google Scholar 

  13. 13

    Matchison, N. A., Fed. Proc., 29, 222 (1970).

    Google Scholar 

  14. 14

    Miller, J. F. A. P., Proc. Roy. Soc. B, 156, 415 (1962).

    ADS  Article  Google Scholar 

  15. 15

    Janković, B. D., Waksman, B. H., and Arnason, B. G., J. Exp. Med., 116, 159 (1962).

    Article  Google Scholar 

  16. 16

    Arnason, B. G., Janković, B. D., Waksman, B. H., and Wennersten, C., J. Exp. Med., 116, 177 (1962).

    CAS  Article  Google Scholar 

  17. 17

    Waksman, B. H., Arnason, B. G., and Janković, B. D., J. Exp. Med., 116, 187 (1962).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

MAEDA, Y., CHIHARA, G. Lentinan, a New Immuno-accelerator of Cell-mediated Responses. Nature 229, 634 (1971). https://doi.org/10.1038/229634a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing