Abstract
ALTHOUGH the catecholamine precursor L-dopa (L-3–4-dihydroxyphenylalanine), like most clinically effective anti-depressant drugs, reverses reserpine-induced brain catecholamine depletion and sedation1–3, early clinical trials using 1.5–3.0 g/day revealed no significant antidepressant activity4–9. Recently, we gave L-dopa to eighteen depressed patients, using the very large oral doses found to be effective in reversing many of the symptoms of Parkinson's disease10–17.
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MURPHY, D., BRODIE, H., GOODWIN, F. et al. Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients. Nature 229, 135–136 (1971). https://doi.org/10.1038/229135a0
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DOI: https://doi.org/10.1038/229135a0
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