Decreased Proliferative Activity of Erythroblasts in Granulocytic Stem Cell Leukaemia


PROOF of reduced reproductive activity of both leukaemic blastocytes in granulocytic stem cell leukaemia and of erythroblasts in Morbus Di Guglielmo2 has previously been obtained using 3H-thymidine (3H-dThd) incorporation, micro-spectrophotometric measurements of DNA content and evaluations of mitotic indices. But no data have been published concerning 3H-dThd incorporation and mitotic activity of erythroblasts in patients suffering from granulocytic stem cell leukaemia. Such data are presented here.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Killmann, S. A., Ser. Haematol., 1/3, 38 (1968).

  2. 2

    Gavosto, F., Maraini, G., and Pileri, A., Blood, 16, 1122 (1960).

  3. 3

    Abbrederis, K., Schmalzl, F., and Braunsteiner, H., Schweiz. Med. Wschr., 99, 1425 (1969).

  4. 4

    Huber, C., Lederer, B., Schmalzl, F., Bütterich, D., Huber, H., and Braunsteiner, H., Acta Haematol. (in the press).

  5. 5

    Bond, V. P., Fliedner, T. M., Cronkite, E. P., Rubini, J. R., and Robertson, J. S. in The Kinetics of Cellular Proliferation (edit. by Stohlman, F., jun.) (Grune and Stratton, New York, 1959).

  6. 6

    Boll, I., and Ganssen, O., Acta Haematol., 27, 229 (1962).

  7. 7

    Whang, J., Frei, E., III, Tjio, J. H., Carbone, P. P., and Brecher, G., Blood, 22, 664 (1963).

  8. 8

    Jensen, M. K., and Killmann, S. A., Acta Med. Scand., 181, 47 (1967).

  9. 9

    Wintrobe, M. M., Clinical Hematology, sixth ed. (Lea and Febiger, Philadelphia, 1967).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HUBER', C., HUBER, H., SCHMALZL, F. et al. Decreased Proliferative Activity of Erythroblasts in Granulocytic Stem Cell Leukaemia. Nature 229, 113–114 (1971).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.