Abstract
INDIRECT immunofluorescent techniques show that the sera of patients with pemphigus vulgaris contain immunoglobulins (IgG) which specifically bind to the presumed site of the intercellular space of stratified squamous epithelia1–3. Pretitres of these diagnostic antibodies reflect the progress of the disease as well as the patient's response to treatment4. There is considerable evidence that the IgG immunoglobulins1,5 and complement6 found in the intercellular spaces represent autoantibodies4. These data imply that the distribution of the IgG deposits corresponds to the primary lesion in this disease7,8.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Beutner, E. H., and Jordon, R. E., Proc. Soc. Exp. Biol. Med., 117, 505 (1964).
Beutner, E. H., Lever, W. F., Witebsky, E., Jordon, R. E., and Chertok, B. L., J. Amer. Med. Assoc., 192, 682 (1965).
Chorzelski, T. P., von Weiss, J., and Lever, W. F., Arch. Dermatol., 93, 570 (1966).
Beutner, E. H., Jordon, R. E., and Chorzelski, T. P., J. Invest. Dermatol., 51, 63 (1968).
Waldorf, D. S., Smith, C. W., and Strauss, A. J., Arch. Dermatol., 93, 28 (1966).
Cormane, R. H., and Chorzelski, T. P., Dermatologica, 134, 463 (1967).
Braun-Falco, O., and Vogell, W., Arch. Klin. Exp. Dermatol., 223, 328 (1965).
Hashimoto, K., and Lever, W. F., J. Invest. Dermatol., 48, 540 (1967).
Avrameas, S., Immunochemistry, 6, 43 (1969).
Graham, R. C., and Karnovsky, M. J., J. Histochem. Cytochem., 14, 291 (1966).
Schreiner, E., and Wolff, K., Arch. Klin. Exp. Dermatol., 235, 78 (1969).
Wolff, K., and Schreiner, E., Arch. Klin. Exp. Dermatol., 235, 203 (1969).
Chorzelski, T. P., Biczyski, W., Dabrowski, J., and Jarzabek, M., J. Invest. Dermatol., 50, 36 (1968).
Wolff, K., and Schreiner, E., J. Invest. Dermatol., 51, 418 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WOLFF, K., SCHREINER, E. Ultrastructural Localization of Pemphigus Autoantibodies within the Epidermis. Nature 229, 59–61 (1971). https://doi.org/10.1038/229059a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/229059a0
This article is cited by
-
A novel method to investigate pemphigus-induced keratinocyte dysmorphisms through living cell immunofluorescence microscopy
Virchows Archiv (2007)
-
Assembly Pathway of Desmoglein 3 to Desmosomes and Its Perturbation by Pemphigus Vulgaris-IgG in Cultured Keratinocytes, as Revealed by Time-Lapsed Labeling Immunoelectron Microscopy
Laboratory Investigation (2000)
-
Binding of autoantibodies is not restricted to desmosomes in pemphigus vulgaris:
Archives of Dermatological Research (1996)
-
Immunology/Inflammation of the Skin—A 50-Year Perspective
Journal of Investigative Dermatology (1989)
-
Ultrastructural and autoradiographic investigation of the skin in acantholytic pemphigus
Bulletin of Experimental Biology and Medicine (1988)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
