Abstract
2,4-DINITROPHENOL (DNP) uncouples oxidative phosphorylation by interfering with mitochondrial activity1,2. It has been widely used to inhibit the metabolism of central or peripheral neural tissue3–5. The reduction in supply of ATP slows ion pumping and so leads to the accumulation of Na+ inside cells and a corresponding loss of K+. Blockage by DNP is therefore a criterion for identifying energy-driven processes.
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GODFRAIND, J., KRNJEVIĆ, K. & PUMAIN, R. Unexpected Features of the Action of Dinitrophenol on Cortical Neurones. Nature 228, 562–564 (1970). https://doi.org/10.1038/228562a0
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DOI: https://doi.org/10.1038/228562a0
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