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Preliminary Experiments on the Chemistry and Pharmacology of Cannabis

Abstract

There are at least six pharmacologically effective components of cannabis. Their effects on mice include a lowering of body temperature, catalepsy, analgesia and an extension of barbiturate sleeping time, with doses from 25 to 200 mg/kg.

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References

  1. 1

    Mechoulam, R., and Gaoni, Y., Progress in the Chemistry of Organic Natural Products, 25, 175 (Springer, New York, 1967).

    Google Scholar 

  2. 2

    Korte, F., and Sieper, H., Annalen, 630, 71 (1960).

    CAS  Article  Google Scholar 

  3. 3

    Miras, C. J., in Hashish, Ciba Foundation Study Group No. 21 (Churchill, London, 1965).

    Google Scholar 

  4. 4

    Garattini, S., in Hashish, Ciba Foundation Study Group No. 21 (Churchill, London, 1965).

    Google Scholar 

  5. 5

    Holtzman, D., Lovell, R. A., Jaffe, J. H., and Freedman, D. X., Science, 163, 1464 (1969).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Herrington, L. P., Amer. J. Physiol., 129, 123 (1940).

    CAS  Google Scholar 

  7. 7

    Loewe, S., J. Pharmac. Exp. Ther., 88, 154 (1946).

    CAS  Google Scholar 

  8. 8

    Siegmund, E., Cadmus, R., and Lu, G., Proc. Soc. Exp. Biol. Med., 95, 729 (1957).

    CAS  Article  Google Scholar 

  9. 9

    Cortez, L., Chaud Sob, J., and Louzada, N. L., Third Internat. Pharmacol. Congr., Abstracts, 667 (1966).

    Google Scholar 

  10. 10

    Bicher, H. I., and Mechoulam, R., Arch. Int. Pharmacodyn., 172, 24 (1968).

    CAS  PubMed  Google Scholar 

  11. 11

    Buxbaum, D., Sanders-Bush, E., and Efron, D. H., Fed. Proc., 28, 735 (1969).

    Google Scholar 

  12. 12

    Loewe, S., Arch. Exp. Path. Pharmak., 211, 175 (1950).

    CAS  Article  Google Scholar 

  13. 13

    Persaud, T. V. N., and Ellingham, A. C., Lancet, ii, 406 (1968).

    Article  Google Scholar 

  14. 14

    Geber, W. F., and Schramm, L. C., Arch. Int. Pharmacodyn., 177, 224 (1969).

    CAS  PubMed  Google Scholar 

  15. 15

    Persaud, T. V. N., and Ellington, A. C., Lancet, 2, 1306 (1967).

    CAS  Article  Google Scholar 

  16. 16

    Paton, W. D. M., Brit. J. Pharmacol., 12, 119 (1957).

    CAS  Google Scholar 

  17. 17

    Paton, W. D. M., and Vizi, E. S., Brit. J. Pharmacol., 35, 10 (1969).

    CAS  Article  Google Scholar 

  18. 18

    Speden, R. N., Brit. J. Pharmacol., 25, 104 (1965).

    CAS  PubMed  Google Scholar 

  19. 19

    Hindmarsh, I., Brit. J. Addiction, 64, 395 (1970).

    Article  Google Scholar 

Download references

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GILL, E., PATON, W. & PERTWEE, R. Preliminary Experiments on the Chemistry and Pharmacology of Cannabis. Nature 228, 134–136 (1970). https://doi.org/10.1038/228134a0

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