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Inhibition by Drugs of Smoking Behaviour in Monkeys

Abstract

THERE have been several analyses of the role of nicotine in smoking. Johnston1 found that heavy smokers reported a pleasurable sensation when given nicotine, whereas non-smokers reported an unpleasant effect. Lucchesi et al.2 showed that intravenous administration of nicotine diminished the number of cigarettes smoked by heavy smokers. Jarvik et al.3 recently obtained a similar result with nicotine taken orally. If, as these studies suggest, nicotine is an incentive in smoking, then drugs which block the action(s) of nicotine should influence smoking.

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References

  1. Johnston, L. M., Lancet, ii, 742 (1942).

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  3. Jarvik, M. E., Glick, S. D., and Nakamura, R. K., Clin. Pharmacol. Ther. (in the press).

  4. Jarvik, M. E., Ann. NY Acad. Sci., 142, 280 (1967).

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GLICK, S., JARVIK, M. & NAKAMURA, R. Inhibition by Drugs of Smoking Behaviour in Monkeys. Nature 227, 969–971 (1970). https://doi.org/10.1038/227969a0

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