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Tetrahydrocannabinol Isomers and Homologues: Contrasted Effects of Smoking


TWO isomers of tetrahydrocannabinol (THC) are found in natural marijuana preparations. 99 per cent is in the form of Δ1(9)-THC, which is very active when taken orally or smoked1,2. A Δ3-THC homologue, synhexyl (pyrahexyl), has been found to be about one-third as active as Δ1-THC, given orally to the same individuals2. The study I report here compared measured doses of Δ1-THC, the Δ3-homologue (synhexyl), and Δ3-THC smoked by the same individuals, using a placebo and blind controls.

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  1. Isbell, H., Gorodetsky, G. W., Jasinski, D., Claussen, U., v. Spulak, F., and Korter, F., Psychopharmacologia, 11, 184 (1967).

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  2. Hollister, L. E., Richards, R. K., and Gillespie, H. K., Clin. Pharmacol. Ther., 9, 783 (1968).

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  3. Song, Chung Hun, Kanter, S. L., and Hollister, L. E., Res. Comm. Chem. Path. Pharmacol., 1, 375 (1970).

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  4. Hollister, L. E., and Gillespie, H. K., Arch. Gen. Psychiat. (in the press).

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HOLLISTER, L. Tetrahydrocannabinol Isomers and Homologues: Contrasted Effects of Smoking. Nature 227, 968–969 (1970).

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