Abstract
The synthesis of haemoglobin in a cell free system containing yeast tRNA is initiated by a specific methionine tRNA. Another methionine tRNA responds to internal codons in the messenger. The initiating methionine is removed from the nascent protein to leave valine as the terminal amino-acid, but cannot be removed when its amino group is blocked as in formylmethionine.
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HOUSMAN, D., JACOBS-LORENA, M., RAJBHANDARY, U. et al. Initiation of Haemoglobin Synthesis by Methionyl-tRNA. Nature 227, 913–918 (1970). https://doi.org/10.1038/227913a0
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DOI: https://doi.org/10.1038/227913a0
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