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Immunosuppressive Effects of Soluble Cell Membrane Fractions, Donor Blood and Serum on Renal Allograft Survival

Nature volume 227, pages 903–906 (1970)Cite this article

Abstract

Soluble cell membrane extracts of liver and spleen have been injected intravenously at the time of renal allografting. In dogs and rhesus monkeys there was slight prolongation of transplant survival in some experiments. Survival was markedly prolonged in 30 per cent of pigs, however. Donor blood and serum had a similar effect in protecting porcine liver allografts from rejection.

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Author information

Authors and Affiliations

  1. Department of Surgery, University of Cambridge,

    R. Y. CALNE, D. R. DAVIS, E. HADJIYANNAKIS, R. A. SELLS & D. WHITE

  2. Department of Pathology, University of Cambridge,

    B. M. HERBERTSON & P. R. MILLARD

  3. Tissue Typing Division, John Bonnett Clinical Laboratories, Addenbrooke's Hospital, Cambridge

    V. C. JOYSEY

  4. Searle Research Laboratories, High Wycombe,

    D. A. L. DAVIES

  5. Department of Experimental Pathology, ARC Institute of Animal Physiology, Babraham

    R. M. BINNS

  6. Transplantation Immunology Unit, London Hospital Medical College, London, E1

    H. FESTENSTEIN

Authors
  1. R. Y. CALNE
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  2. D. R. DAVIS
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  3. E. HADJIYANNAKIS
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  4. R. A. SELLS
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  5. D. WHITE
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  6. B. M. HERBERTSON
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  7. P. R. MILLARD
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  8. V. C. JOYSEY
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  9. D. A. L. DAVIES
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  10. R. M. BINNS
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  11. H. FESTENSTEIN
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CALNE, R., DAVIS, D., HADJIYANNAKIS, E. et al. Immunosuppressive Effects of Soluble Cell Membrane Fractions, Donor Blood and Serum on Renal Allograft Survival. Nature 227, 903–906 (1970). https://doi.org/10.1038/227903a0

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