Abstract
A single dose of splenic extract is sufficient to induce a high degree of specific unresponsiveness to skin allografts in mice if used in conjunction with antilymphocytic serum. The interval between giving the extract and the antiserum is of great importance, and the unresponsiveness appears to be due to tolerance rather than enhancement.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Histocompatibility Testing 1970 (Munksgaard, Copenhagen, 1970).
Monaco, A. P., Wood, M. L., and Russell, P. S., Ann. NY Acad. Sci., 129, 190 (1966).
Lance, E. M., and Medawar, P. B., Proc. Roy. Soc., B, 173, 447 (1969).
Simonsen, M., Acta Pathol. Microbiol. Scand., 40, 480 (1957).
Billingham, R. E., and Brent, L., Phil. Trans. Roy. Soc., B, 242, 439 (1959).
Billingham, R. E., Brent, L., and Medawar, P. B., Transpl. Bull., 5, 377 (1958).
Medawar, P. B., Transplantation, 1, 21 (1963).
Martinez, C., Smith, J. M., Blaese, M., and Good, R. A., J. Exp. Med., 118, 743 (1963).
Calne, R. Y., Davis, D. R., Medawar, P. B., and Wheeler, J. R., Transplantation, 4, 742 (1966).
Levey, R. H., and Medawar, P. B., Ann. NY Acad. Sci., 129, 164 (1966).
Billingham, R. E., and Medawar, P. B., J. Exp. Biol., 28, 385 (1951).
French, M. E., and Batchelor, J. R., Lancet, ii, 1103 (1969).
Kaliss, N., Proc. Soc. Exp. Biol. and Med., 129, 83 (1968).
Lance, E. M., Ford, P. J., and Ruskiewicz, M., Immunology, 15, 571 (1968).
Harder, F. H., and McKhann, C. F., J. Nat. Cancer. Inst., 40, 231 (1968).
Abbott, W. M., Monaco, A. P., and Russell, P. S., Transplantation, 7, 291 (1969).
Mitchison, N. A., Fed. Proc., 29, 222 (1970).
Wilson, R. E., Rippin, A., Dagher, R. K., Kinneart, P., and Busch, G. J., Transplantation, 7, 360 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRENT, L., KILSHAW, P. Prolongation of Skin Allograft Survival with Spleen Extracts and Antilymphocytic Serum. Nature 227, 898–900 (1970). https://doi.org/10.1038/227898a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227898a0
This article is cited by
-
Genetic factors in allograft unresponsiveness
Survey of Immunologic Research (1983)
-
Die allogene Lebertransplantation
Research in Experimental Medicine (1981)
-
Aktives Enhancement von Hundeleberallotransplantaten Vorbehandlung mit polyspezifischem semisolublen Milzalloantigen
Langenbecks Archiv f�r Chirurgie (1977)
-
Der Effekt der spenderspezifischen Antigen-Typen auf aktives Enhancement der Rattennierenallotransplantate bei histoinkompatibilen Inzucht-Ratten
Research in Experimental Medicine (1975)
-
197. Induktion und Erhaltung immunologischer Transplantattoleranz beim erwachsenen Organismus
Langenbecks Archiv für Chirurgie (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
