Abstract
IT is not yet clear whether the cytotoxicity observed when target cells and allogeneic lymphoid cells are cultured together in vitro1,2 is mediated by an immunological mechanism. Cell death has been attributed to contact with the antigenically or structurally incompatible lymphocyte cell surface rather than by any conventional immunological reaction2,3. Thus any cell type carrying foreign histocompatibility antigens would be able to cause target cell death. The following experiments were carried out to test this hypothesis.
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MITCHELL, C. Importance of Immunologically Competent Cells in Contact-induced Cytotoxicity. Nature 227, 846–847 (1970). https://doi.org/10.1038/227846a0
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DOI: https://doi.org/10.1038/227846a0
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