Abstract
NOELL1 first showed that the c-wave of the vertebrate-electroretinogram (ERG) probably originates in the pigment epithelium because the c-wave disappeared in the rabbit after selective poisoning of the pigment epithelium by sodium iodate. Brown and Wiesel showed that the c-wave of the cat's local ERG attained maximum amplitude when the electrode was immediately adjacent to the pigment epithelium2. They also obtained more direct evidence during brief intracellular recordings from pigment epithelial cells, which revealed larger potentials of similar time course but opposite polarity to the c-wave2. We have now obtained stable intracellular recordings which permit the slow light-evoked responses of pigment epithelial cells to be described in detail and identified positively as the origin of the c-wave.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Noell, W. K., Amer. J. Ophthalmol., 38, 78 (1954).
Brown, K. T., and Wiesel, T. N., J. Physiol., 158, 257 (1961).
Steinberg, R. H., Vision Res., 9, 317 (1969).
Steinberg, R. H., Vision Res., 9, 1319 (1969).
Brown, K. T., and Tasaki, K., J. Physiol., 158, 281 (1961).
Steinberg, R. H., and Schmidt, R., Vision Res. (in the press).
Young, R. W., The Retina, 177 (University of California, Los Angeles and Berkeley, 1969).
Potter, D. D., Furshpan, E. J., and Lennox, E. S., Proc. US Nat. Acad. Sci., 55, 328 (1966).
Payton, B. W., Bennett, M. V. L., and Pappas, G. D., Science, 166, 1641 (1969).
Orkand, R. A., Nicholls, J. G., and Kuffler, S. W., J. Neurophysiol., 29, 788 (1966).
Steinberg, R. H., Vision Res., 9, 1331 (1969).
Meservey, A. B., and Chaffee, E. L., J. Opt. Soc. Amer., 15, 311 (1927).
Arden, G. B., and Tansley, K., J. Physiol., 127, 592 (1955).
Crescitelli, F., Vision Res., 1, 139 (1961).
Tigges, J., Brooks, B. A., and Klee, M. R., Vision Res., 7, 553 (1967).
Granit, R., and Riddell, L. A., J. Physiol., 88, 436 (1937).
Granit, R., and Munsterhjelm, A., J. Physiol., 88, 436 (1937).
Dodt, E., Bibl. Ophthalmol., 48, 32 (1957).
Liebman, P. A., Rice, R., Carrol, S., Entine, G., and Laties, A., Invest. Ophthalmol., 6, 214 (1967).
Brown, K. T., and Crawford, J. M., Vision. Res., 7, 165 (1967).
Yamada, E., Tokuyasu, K., and Iwaki, S., J. Electron Microscopy, 6, 42 (1958).
Cohen, A. I., Exp. Eye Res., 1, 128 (1961).
Baraiti, jun., A., and Orzalesi, N., J. Ultrastruct. Res., 9, 484 (1963).
Kuffler, S. W., and Nicholls, J. G., Ergebn. Physiol., 57, 2 (1966).
Berman, E. R., and Bach, G., Biochem. J., 108, 75 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STEINBERG, R., SCHMIDT, R. & BROWN, K. Intracellular Responses to Light from Cat Pigment Epithelium: Origin of the Electroretinogram c-Wave. Nature 227, 728–730 (1970). https://doi.org/10.1038/227728a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/227728a0
This article is cited by
-
Electroretinogram responses in myopia: a review
Documenta Ophthalmologica (2022)
-
Electroretinogram analysis of zebrafish retinal function across development
Documenta Ophthalmologica (2021)
-
Abnormal Electroretinogram after Kir7.1 Channel Suppression Suggests Role in Retinal Electrophysiology
Scientific Reports (2017)
-
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
Scientific Reports (2017)
-
Phytochemical analysis and effects of Pteris vittata extract on visual processes
Journal of Natural Medicines (2016)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
