Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Synthetic Sweetener Consumption and Bladder Cancer Trends in the United States

Abstract

RECENT experimental evidence has demonstrated that high doses of synthetic sweeteners cause bladder cancer in rodents. In rats, the oral administration of a cyclamate–saccharine mixture alone or combined with cyclohexylamine, a metabolite of cyclamate, induced a high frequency of bladder carcinoma1. These tumours also developed in mice after bladder implantation of cholesterol–cyclamate or cholesterol–saccharine pellets1,2. These studies prompted the Department of Health, Education and Welfare to restrict the general use of cyclamates and to undertake further laboratory studies on the toxicity of synthetic sweeteners. As a first step in evaluating whether synthetic sweeteners are carcinogenic in man, we have examined the consumption patterns of these agents and the trends for bladder cancer in the United States.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Anonymous, J. Amer. Med. Ass., 210, 795 (1969).

  2. Ad hoc Committee on Nonnutritive Sweeteners, Food Protection Committee, Nonnutritive Sweeteners, An Interim Report to the US Food and Drug, Administration, Department of Health, Education and Welfare (National Academy of Sciences—National Research Council, November 1968).

  3. Eisenberg, H., Cancer in Connecticut, Incidence and Rates, 1935–62, 30 and 60 (State Department of Health, Hartford, Connecticut, 1966).

    Google Scholar 

  4. Eisenberg, H., Cancer in Connecticut, Annual Reports 1963 and 1964, (State Department of Health, Hartford, Connecticut).

  5. Ferber, B., Handy, V. H., Gerhardt, P. R., and Solomon, M., Cancer in New York State, Exclusive of New York City, 1941–1960, A Review of Incidence, Mortality, Probability, and Survivorship, 42 (State Department of Health, Albany, New York, 1962).

    Google Scholar 

  6. Fraumeni, jun., J. F., J. Nat. Cancer Inst., 41, 1205 (1968).

    PubMed  Google Scholar 

  7. King, H., and Bailar, J. C., III, J. Chron. Dis., 19, 735 (1966).

    Article  CAS  Google Scholar 

  8. Legator, M. S., Palmer, K. A., Green, S., and Petersen, K. W., Science, 165, 1139 (1969).

    Article  ADS  CAS  Google Scholar 

  9. Stone, D., Lamson, E., Chang, Y. S., and Pickering, K. W., Science, 164, 568 (1969).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

BURBANK, F., FRAUMENI, J. Synthetic Sweetener Consumption and Bladder Cancer Trends in the United States. Nature 227, 296–297 (1970). https://doi.org/10.1038/227296a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/227296a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing