Abstract
A SUBSTRUCTURE of hexagonally arranged subunits has been reported in the luminal membrane of the superficial cells lining the rat urinary bladder1,2. Preliminary examination of electron micrographs of negatively stained membranes in an optical diffractometer (unpublished observations of R. M. H., K. W. Horne and G. J. Hills) suggested that each subunit was a hexamer composed of six smaller particles. Vergara, Langley and Robertson3 described a similar hexagonal lattice in the mouse bladder luminal membrane. Their optical filtering technique revealed a lattice of hexamers skewed by 19° to the axis of the lattice. This communication describes how further detail has been resolved in the substructure of the membrane by a modification of the linear integration technique of Markham, Hitchborn, Hills and Frey4.
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References
Hicks, R. M., and Ketterer, B., Proc. Roy. Microsc. Soc., 4, 118 (1969).
Hicks, R. M., and Ketterer, B., Nature, 224, 1304 (1969).
Vergara, J., Langley, W., and Robertson, J. D., J. Mol. Biol., 46, 593 (1969).
Markham, R., Hitchborn, J. H., Hills, G. J., and Frey, S., Virology, 22, 342 (1964).
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WARREN, R., HICKS, R. Structure of the Subunits in the Thick Luminal Membrane of Rat Urinary Bladder. Nature 227, 280–281 (1970). https://doi.org/10.1038/227280b0
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DOI: https://doi.org/10.1038/227280b0
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