Reactivity of anti-D Immunoglobulin G Subunits


IgG anti-A1 and IgM anti-B2 antibodies have been shown to bind by two binding sites to the surface of human group A and B cells respectively. I now report that IgG anti-D, on the other hand, only binds through one of the binding sites on the IgG molecule to Rh-positive red cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Greenbury, C. L., Moore, D. H., and Nunn, L. A. C., Immunology, 8, 420 (1965).

  2. 2

    Economidou, J., Hughes-Jones, N. C., and Gardner, B., Immunology, 13, 235 (1967).

  3. 3

    Mitchison, N. A., in Differentiation and Immunology (edit. by Warren, K. B.) (Academic Press, New York and London, 1968).

  4. 4

    Porter, R. R., Biochem. J., 73, 119 (1959).

  5. 5

    Osterland, C. K., Harboe, M., and Kunkel, H. G., Vox Sang., 8, 133 (1963).

  6. 6

    Medgyesi, G. A., and Gergely, J., Immunochemistry, 6, 473 (1969).

  7. 7

    Mcfarlane, A. S., Nature, 182, 53 (1958).

  8. 8

    Rochna, E., and Hughes-Jones, N. C., Vox Sang., 10, 675 (1965).

  9. 9

    Hughes-Jones, N. C., Immunology, 12, 565 (1967).

  10. 10

    Nissonof, A., Wissler, F. C., and Woernley, D. L., Arch. Biochem. Biophys., 88, 241 (1960).

  11. 11

    Pollack, W., Ann. NY Acad. Sci., 127, 892 (1965).

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

HUGHES-JONES, N. Reactivity of anti-D Immunoglobulin G Subunits. Nature 227, 174–175 (1970).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.