Proteolytic Enzymes Initiating Cell Division and Escape from Contact Inhibition of Growth

Abstract

BRIEF treatment with very low concentrations of proteolytic enzymes can bring about a change in the cell surface similar to that occurring in the chemical or viral transformation of normal to malignant cells1. This suggests to us that proteolytic enzymes may not only convert the surface structure into the type seen in malignant cells but that the whole cell may respond to the proteolytic enzyme with initiation of new rounds of cell division and a concomitant escape from contact inhibition of growth, as is the case for malignant cells in tissue culture2.

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BURGER, M. Proteolytic Enzymes Initiating Cell Division and Escape from Contact Inhibition of Growth. Nature 227, 170–171 (1970). https://doi.org/10.1038/227170a0

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