Characteristics of a Human Diploid Cell Designated MRC-5

Article metrics


THE stability and integrity of the human foetal cell strain WI-38, which has been well demonstrated in the past ten years1–3, and its susceptibility to viruses infective for man1,4, explain the value of such material for the isolation of viruses and in the development of vaccines5–8. We have developed another strain of cells, also derived from foetal lung tissue, taken from a 14-week male foetus removed for psychiatric reasons from a 27 year old woman with a genetically normal family history and no sign of neoplastic disease both at abortion and for at least three years afterwards. The criteria used for characterizing the cells are those recommended internationally2,9.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Hayflick, L., and Moorhead, P. S., Exp. Cell. Res., 25, 585 (1961).

  2. 2

    Minutes Fifth Meeting Committee on Cell Cultures, Permanent Section on Microbiological Standardization, 40 (Intern. Assoc. Microbiol. Socs., 1968).

  3. 3

    Trlifajova, J., and Strizova, V., J. Hyg. Epidemiol. Microbiol. Immunol., 10, 510 (1966).

  4. 4

    Herrman, jun., E. C., Amer. J. Epidemiol., 85, 200 (1967).

  5. 5

    Hayflick, L., Plotkin, S. A., Norton, T. W., and Koprowski, H., Amer. J. Hyg., 75, 240 (1962).

  6. 6

    Ikie, D., Prog. Immunobiol., 2, 305 (1965).

  7. 7

    Chanock, R. M., Ludwig, W., Huebner, R. J., Cate, T. R., and Liang-Wei Chu, J. Amer. Med. Assoc., 195, 445 (1966).

  8. 8

    Plotkin, S. A., Farquhar, J., Katz, M., and Ingalls, T., Amer. J. Epidemiol., 86, 468 (1967).

  9. 9

    Proc. Symp. on Characterization and Uses of Human Diploid Cell Strains, Opatija, Yugoslavia, 1963, 709).

  10. 10

    McCarthy, K., Taylor-Robinson, C. H., and Pillinger, S. E., Lancet, ii, 593 (1963).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

JACOBS, J., JONES, C. & BAILLE, J. Characteristics of a Human Diploid Cell Designated MRC-5. Nature 227, 168–170 (1970) doi:10.1038/227168a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.