Multiple Antibiotic Resistance in a Bacterium with Suppressed Autolytic System

Abstract

Suppression of the activity of the cellular autolytic system of pneumococci causes simultaneous resistance against penicillin, D-cycloserine and phosphonomycin. This phenomenon represents a novel type of drug resistance mechanism in bacteria.

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References

  1. 1

    McQuillen, K., in The Bacteria (edit. by Gunsalus. I. C., and Stanier. R. Y.), 1, 243 (Academic Press, New York, 1960).

  2. 2

    Wise, E. M., and Park, J. T., Proc. US Nat. Acad. Sci., 54, 75 (1965).

  3. 3

    Tipper, D. J., and Strominger, J. L., Proc. US Nat. Acad. Sci., 54, 1133 (1965).

  4. 4

    Izaki, K., Matsuhashi, M., and Strominger, J. L., Proc. US Nat. Acad. Sci., 55, 656 (1966).

  5. 5

    Strominger, J. L., Ito, E., and Threnn, R. H., J. Amer. Chem. Soc., 82, 998 (1960).

  6. 6

    Hendlin, D., Stapley, E. O., Jackson, M., Wallick, H., Miller, A. K., Wolf, F. J., Miller, T. W., Chaiet, L., Kahan, F. M., Foltz, E. L., Woodruff, H. B., Mata, J. M., Hernandez, S., and Mochales, S., Science, 166, 122 (1969).

  7. 7

    Weidel, W., and Pelzer, H., Adv. Enzymol., 26, 193 (1964).

  8. 8

    Mitchell, P., and Moyle, J., J. Gen. Microbiol., 16, 184 (1957).

  9. 9

    Shockman, G. D., Kolb, J. J., and Toennis, G., J. Biol. Chem., 230, 961 (1958).

  10. 10

    Weidel, W., Frank, H., and Martin, H. H., J. Gen. Microbiol., 22, 158 (1960).

  11. 11

    Schwarz, U., and Weidel, W., Z. Naturforsch., 20b, 147 (1965).

  12. 12

    Schwarz, U., Asmus, A., and Frank, H., J. Mol. Biol., 41, 419 (1969).

  13. 13

    Leutgeb, W., and Schwarz, U., Z. Naturforsch., 22b, 545 (1967).

  14. 14

    Tomasz, A., Science, 157, 694 (1967).

  15. 15

    Tomasz, A., Proc. US Nat. Acad. Sci., 59, 86 (1968).

  16. 16

    Mosser, J., and Tomasz, A., J. Biol. Chem., 245, 287 (1970).

  17. 17

    Lacks, S., J. Bact., 101, 373 (1970).

  18. 18

    Wood, Jun., W. B., and Smith, M. R., J. Exp. Med., 103, 487 (1956).

  19. 19

    Ghuysen, J-M., Bact. Rev., 32, 425 (1968).

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TOMASZ, A., ALBINO, A. & ZANATI, E. Multiple Antibiotic Resistance in a Bacterium with Suppressed Autolytic System. Nature 227, 138–140 (1970). https://doi.org/10.1038/227138a0

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