Abstract
LUMINOUS bacteria have been used extensively to study drug action1, although studies of general anaesthetics in such systems have been limited to the effects of pressure on the inhibition of luminescence by ether and chloroform2. The luminescent intensity, which is relatively easy to measure, provides a direct indication of the effect of drugs on certain cellular processes. We believed that the use of luminous bacteria as a model system would offer an insight into the action of anaesthetics without many of the complications which occur in general anaesthesia of mammals.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Johnson, F. H., Eyring, H., and Polissar, M. J., The Kinetic Basis of Molecular Biology (Wiley, New York, 1954).
Johnson, F. H., J. Cell. Comp. Physiol., 20, 269 (1942).
Farghaly, A. H., J. Cell. Comp. Physiol., 36, 165 (1950).
Harvey, E. N., Bioluminescence (Academic Press, New York, 1952).
Johnson, F. H., J. Cell. Comp. Physiol., 20, 247 (1942).
Harvey, E. N., J. Gen. Physiol., 11, 469 (1928).
Taylor, G. W., J. Cell. Comp. Physiol., 1, 297 (1932).
Taylor, G. W., J. Cell. Comp. Physiol., 4, 329 (1934).
McElroy, W. D., in The Bacteria (edit. by Gunsalus, I. C., and Stanier, R. Y.), 2, 479 (Academic Press, New York, 1961).
Eymers, G., and Van Schouwenburg, K. L., Enzymologia, 1, 328 (1937).
Harvey, E. N., Proc. Amer. Phil. Soc., 71, 135 (1932).
Cormier, M. J., and Totter, J. R., Ann. Rev. Biochem., 33, 431 (1964).
Miller, K. W., Paton, W. D. M., and Smith, E. B., Brit J. Anaesth., 39, 910 (1967).
Raventos, J., Brit. J. Pharmacol., 11, 394 (1956).
Cherkin, A., in Structural Chemistry and Molecular Biology (edit. by Rich, A., and Davidson, N. I.), 325 (Freeman, 1968).
Epstein, R. M., Ngai, S. H., and Popper, E. M., Fed. Proc., 21, 329B (1962).
Miller, K. W., Paton, W. D. M., and Smith, E. B., Nature, 206, 574 (1965).
Eger, E. I., Anaesthesiology, 30, 129 (1969).
Pauling, L., Science, 134, 15 (1961).
Miller, S. L., Proc. US Nat. Acad. Sci., 47, 1515 (1961).
Smith, E. B., in Physiology and Medicine of Diving (edit. by Bennet and Elliot), chapter 8 (Baillière, Tindall and Cassell, London, 1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HALSEY, M., SMITH, E. Effects of Anaesthetics on Luminous Bacteria. Nature 227, 1363–1365 (1970). https://doi.org/10.1038/2271363b0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2271363b0
This article is cited by
-
Do general anaesthetics act by competitive binding to specific receptors?
Nature (1984)
-
Molecular mechanisms of general anaesthesia
Nature (1982)
-
The response of the honeybee antennal CO2-receptors to N2O and Xe
Journal of Comparative Physiology (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.