Is there a Unique Conformation of Cholinergic Ligands responsible for Muscarinic Activity ?

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Abstract

CHOTHIA1 has proposed a structure activity relationship for the muscarinic response of acetylcholine. In deriving the model responsible for optimum activity, reports on the pharmacological testing of a number of conformationally constrained acetylcholine analogues were neglected.

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SHEFTER, E., TRIGGLE, D. Is there a Unique Conformation of Cholinergic Ligands responsible for Muscarinic Activity ?. Nature 227, 1354–1355 (1970) doi:10.1038/2271354a0

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