Three Variable-Gene Pools common to IgM, IgG and IgA Immunoglobulins

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Abstract

Comparison of the NH2-terminal region of several α, γ and μ chains indicates that four variable-sequence subgroups are common to heavy chains. The existence of three independent variable-gene pools common to the three major immunoglobulin classes is confirmed.

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KÖHLER, H., SHIMIZU, A., PAUL, C. et al. Three Variable-Gene Pools common to IgM, IgG and IgA Immunoglobulins. Nature 227, 1318–1320 (1970) doi:10.1038/2271318a0

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