In vivo Specific Antigen Recognition by Rosette Forming Cells

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Abstract

THE rosette test has been used extensively for the study of antibody forming cells1,2, but few data are available on rosette formation in unimmunized animals1,3. Most “spontaneous” rosette forming cells (RFC) in the spleens of unimmunized mice are small lymphocytes4 bearing immunoglobulin receptors5 specific for the antigen3; RFC against chicken erythrocytes are present before birth3. There is no correlation between the number of RFC in the spleen and the level of the corresponding humoral antibodies1.

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BACH, J., MULLER, J. & DARDENNE, M. In vivo Specific Antigen Recognition by Rosette Forming Cells. Nature 227, 1251–1252 (1970) doi:10.1038/2271251a0

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