Release of Elastolytic Activity from Blood Platelets

Article metrics

Abstract

THE degradation of elastin early in atherosclerosis1 has been attributed to elastolytic enzymes of the blood or vessel wall2, but no enzyme other than pancreatic elastase (EG 3.4.4.7) (ref. 2) has yet been demonstrated conclusively. We have recently reported the presence of an elastolytic enzyme in blood platelets3 and now present evidence that it can be released from blood platelets by certain factors which produce aggregation and viscous metamorphosis of platelets. The elastolytic enzyme(s) can be separated from acid cathepsins and partially purified4.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Perrin, A., Loire, R., in Le Rôle de la Paroi Artérielle dans l'Athérogénèse, 1, 141 (Colloque CNRS, Paris, 1967).

  2. 2

    Banga, I., Structure and Function of Elastin and Collagen (Akadémiai Kiado, Budapest, 1966).

  3. 3

    Robert, B., Legrand, Y., Pignaud, G., Caen, J., and Robert, L., Pathol. Biol. Semaine Hop., 17, 615 (1969).

  4. 4

    Legrand, Y., Robert, B., Szigeti, M., Pignaud, G., Caen, J., and Robert, L., Atherosclerosis (in the press).

  5. 5

    Robert, B., and Cambier, D., Bull. Soc. Chim. Biol., 46, 283 (1963).

  6. 6

    Robert, B., and Robert, L., Europ. J. Biochem., 11, 62 (1969).

  7. 7

    Duve, C. de, in Lysosomes (Ciba Foundation Symp.) (Little, Brown and Co., Boston, 1963).

  8. 8

    Pfleiderer, T., in Atherosclerosis (edit. by Schettler, F. G., and Boyd, G. S.), 487 (Elsevier, Amsterdam, 1969).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ROBERT, B., SZIGETI, M., ROBERT, L. et al. Release of Elastolytic Activity from Blood Platelets. Nature 227, 1248–1249 (1970) doi:10.1038/2271248a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.