Effects of L-Asparaginase on Lymphocyte-Target Cell Reactions in vitro

Article metrics


L-ASPARAGINASE was, until recently, thought to be a specific antileukaemic agent. It has recently been shown, however, to be an immimosuppressive agent, inhibiting antibody production1, lymphocyte transformation2,3, the graft-versus-host reaction4, and graft rejection5. We have investigated its effects in an in vitro system in which rat lymphocytes react to monolayers of mouse embryo cells, first undergoing transformation and then lysing the latter6.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Berenbaum, M. C., Nature, 225, 550 (1970).

  2. 2

    Astaldi, G., Burgio, G. R., Krč, J., Genova, R., and Astaldi, jun., A. A., Lancet, i, 423 (1969).

  3. 3

    McElwain, T. J., and Hayward, S. K., Lancet, i, 527 (1969).

  4. 4

    Hobik, H. P., Naturwissenschaften, 56, 217 (1969).

  5. 5

    Schulten, H. K., Giraldo, G., Boyse, E. A., and Oettgen, H. F., Lancet, ii, 644 (1969).

  6. 6

    Ginsburg, H., Immunology, 14, 621 (1968).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

BERENBAUM, M., GINSBURG, H. & GILBERT, D. Effects of L-Asparaginase on Lymphocyte-Target Cell Reactions in vitro. Nature 227, 1147–1148 (1970) doi:10.1038/2271147a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.