Abstract
L-ASPARAGINASE was, until recently, thought to be a specific antileukaemic agent. It has recently been shown, however, to be an immimosuppressive agent, inhibiting antibody production1, lymphocyte transformation2,3, the graft-versus-host reaction4, and graft rejection5. We have investigated its effects in an in vitro system in which rat lymphocytes react to monolayers of mouse embryo cells, first undergoing transformation and then lysing the latter6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Berenbaum, M. C., Nature, 225, 550 (1970).
Astaldi, G., Burgio, G. R., Krč, J., Genova, R., and Astaldi, jun., A. A., Lancet, i, 423 (1969).
McElwain, T. J., and Hayward, S. K., Lancet, i, 527 (1969).
Hobik, H. P., Naturwissenschaften, 56, 217 (1969).
Schulten, H. K., Giraldo, G., Boyse, E. A., and Oettgen, H. F., Lancet, ii, 644 (1969).
Ginsburg, H., Immunology, 14, 621 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BERENBAUM, M., GINSBURG, H. & GILBERT, D. Effects of L-Asparaginase on Lymphocyte-Target Cell Reactions in vitro. Nature 227, 1147–1148 (1970). https://doi.org/10.1038/2271147a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2271147a0
This article is cited by
-
In silico analysis of L-asparaginase from different source organisms
Interdisciplinary Sciences: Computational Life Sciences (2014)
-
Elimination of large pyroninophilic cells by the action of phytohemagglutinin
Bulletin of Experimental Biology and Medicine (1975)
-
Morphological and autoradiographic changes in immune lymphocytes on reacting with allogeneic target cells
Bulletin of Experimental Biology and Medicine (1972)
-
Effect of L-Asparaginase on Germinal Centre Haemolysin
Nature (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
