Asparaginyl-tRNA and Resistance of Murine Leukaemias to L-Asparaginase

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Abstract

INTEREST in the enzyme L-asparaginase has been stimulated by the observation that it inhibits the growth of experimental and human tumours1–3. Tumours sensitive to L-asparaginase require exogenous L-asparagine whereas tumours not sensitive synthesize L-asparagine from L-aspartic acid and L-glutamine. Moreover, if L-asparaginase-sensitive tumours are made resistant using suboptimal doses of the enzyme, the resistant variant possesses L-asparagine synthetase and no longer requires exogenous L-asparagine for growth3,4. The critical questions now concern the regulation of L-asparagine synthetase activity.

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GALLO, R., LONGMORE, J. & ADAMSON, R. Asparaginyl-tRNA and Resistance of Murine Leukaemias to L-Asparaginase. Nature 227, 1134–1136 (1970) doi:10.1038/2271134a0

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