Inhibition of Vaccinia Virus Growth by 1-Methyl-4-aminopiperazine

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RIFAMPICIN inhibits the replication of poxvirus1,2; experiments with other rifamycin derivatives suggested that the hydrazone side-chain of rifampicin was essential for its antiviral activity3. We describe here the action of the characteristic component of this side-chain, l-methyl-4-aminopiperazine, and compare it with that of the other analogue of rifampicin, 3-formylrifamycin SV (FSV), and another compound, l-methyl-4-benzylidenaminopiperazine, which contains the hydrazone side-chain but not the rifamycin moiety.

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  1. 1

    Heller, E., Argaman, M., Levy, H., and Goldblum, N., Nature, 222, 273 (1969).

  2. 2

    Subak-Sharpe, J. H., Timbury, M. C., and Williams, J. F., Nature, 222, 341 (1969).

  3. 3

    Ben-Ishai, Z., Heller, E., Goldblum, N., and Becker, Y., Nature, 224, 29 (1969).

  4. 4

    Bach, M. K., and Johnson, H. G., Biochemistry, 6, 1916 (1967).

  5. 5

    Kates, J., Dahl, R., and Mielke, M., J. Virol., 2, 894 (1968).

  6. 6

    McAuslan, B. R., Biochem. Biophys. Res. Commun., 37, 289 (1969).

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THIRY, L., LANCINI, G. Inhibition of Vaccinia Virus Growth by 1-Methyl-4-aminopiperazine. Nature 227, 1048–1050 (1970) doi:10.1038/2271048a0

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