Inhibition of Vaccinia Virus Growth by 1-Methyl-4-aminopiperazine

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Abstract

RIFAMPICIN inhibits the replication of poxvirus1,2; experiments with other rifamycin derivatives suggested that the hydrazone side-chain of rifampicin was essential for its antiviral activity3. We describe here the action of the characteristic component of this side-chain, l-methyl-4-aminopiperazine, and compare it with that of the other analogue of rifampicin, 3-formylrifamycin SV (FSV), and another compound, l-methyl-4-benzylidenaminopiperazine, which contains the hydrazone side-chain but not the rifamycin moiety.

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References

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THIRY, L., LANCINI, G. Inhibition of Vaccinia Virus Growth by 1-Methyl-4-aminopiperazine. Nature 227, 1048–1050 (1970) doi:10.1038/2271048a0

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