Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring double-stranded DNA as template and yielding a principally double-stranded product.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Baltimore, D., Nature, 226, 1209 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Kornberg, A., Enzymatic Synthesis of DNA, 103 (John Wiley, New York and London, 1961).
Goulian, M., Kornberg, A., and Sinsheimer, R. L., Proc. US Nat. Acad. Sci., 58, 2321 (1967).
Denhardt, D. T., Biochem. Biophys. Res. Commun., 23, 641 (1966).
Gillespie, D., and Spiegelman, S., J. Mol. Biol., 12, 829 (1965).
Warnaar, S. O., and Cohen, J. H., Biochem. Biophys. Res. Commun., 24, 554 (1966).
Rights and permissions
About this article
Cite this article
SPIEGELMAN, S., BURNY, A., DAS, M. et al. DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses. Nature 227, 1029–1031 (1970). https://doi.org/10.1038/2271029a0
This article is cited by
The Antisense Transcriptome and the Human Brain
Journal of Molecular Neuroscience (2016)
Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation
Nature Structural & Molecular Biology (2012)
RNA sequencing: advances, challenges and opportunities
Nature Reviews Genetics (2011)
Direct RNA sequencing
The chronology of AIDS research
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.