Abstract
THE study of mice experimentally infected with murine leukaemia virus (MuLV) has revealed leukaemogenic activity in the milk, saliva, urine and faeces, and typical MuLV particles in the mammary glands, salivary glands, and pancreas. MuLV has not been demonstrated, however, in the excretions or secretions of naturally infected mice1–3. The development by Hartley et al.4,5 of the complement fixation test for murine leukaemia virus provided a sensitive in vitro assay for MuLV and a practical means for the detection of virus in tissues, mouth swabs and excretions. We report here studies on the isolation of virus from excretions and secretions of naturally infected high leukaemia strains AKR/J, C58/J and SJL/J.
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References
Buffett, R. F., Grace, jun., J. T., DiBernardino, L. A., and Mirand, E. A., Cancer Res., 29, 588 (1969).
Law, L. W., Nat. Cancer Institute Monog., 22, 267 (1966).
Gross, L., and Dreyfuss, Y., in Carcinogenesis: A Broad Critique, Twentieth Annual Symposium on Fundamental Cancer Research (Williams and Wilkins, Baltimore, 1968).
Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., Proc. US Nat. Acad. Sci., 53, 931 (1965).
Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).
Rhim, J. S., and Huebner, R. J., Proc. Amer. Assoc. Cancer Res., 9, 60 (1968).
Rhim, J. S., Williams, jun., L. B., Huebner, R. S., and Turner, H. C., Cancer Res., 29, 154 (1969).
Aoki, T., Boyse, E. A., and Old, L. J., J. Nat. Cancer Inst., 41, 103 (1968).
Huebner, R. J., and Todaro, G. J., Proc. US Nat. Acad. Sci., 64, 1078 (1969).
Meier, H., and Myers, D. D., Fed. Proc., 28, 298 (1969).
Meier, H., Myers, D. D., and Huebner, R. J., Proc. US Nat. Acad. Sci., 63, 759 (1969).
Lilly, F., J. Exp. Med., 127, 465 (1968).
Rubin, H., Cancer Res., 21, 1244 (1961).
Bernhard, W., Prog. Exp. Tumor Res., 3, 1 (1963).
Harris, R. J. C., in Fifteenth Annual Symposium on Fundamental Cancer Research, 331 (Williams and Wilkins, Baltimore, 1963).
Vogt, P. K., Cancer Res., 23, 1519 (1963).
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MYERS, D., MEIER, H., RHIM, J. et al. Excretion of Murine Leukaemia Virus. Nature 226, 849–850 (1970). https://doi.org/10.1038/226849a0
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DOI: https://doi.org/10.1038/226849a0
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