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Effect of γ-Chlordane on Synchronized Lymphoma Cells and Inhibition of Cell Division

Nature volume 226, pages 548–549 (1970)Cite this article

Abstract

BOTH acute and chronic toxicities are exhibited by human and murine cells grown in culture in the presence of chlorinated hydrocarbon pesticides1–5. To learn more about the underlying mechanisms responsible for the acute toxicity, we have examined the effects of γ-chlordane on cell division and DNA synthesis utilizing synchronized mouse leukaemia cells (L-5178Y) grown in suspension culture. Synchronized cells provide a means of amplifying a toxic response which ultimately should provide significant clues to the nature of the molecular mechanisms of chlordane toxicity.

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Authors and Affiliations

  1. National Institute of Environmental Health Sciences, National Institutes of Health, Public Health Service, and Department of Health, Education and Welfare Research, Triangle Park, North Carolina, 27709

    P. E. BRUBAKER, W. G. FLAMM & N. J. BERNHEIM

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  1. P. E. BRUBAKER
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  2. W. G. FLAMM
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  3. N. J. BERNHEIM
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BRUBAKER, P., FLAMM, W. & BERNHEIM, N. Effect of γ-Chlordane on Synchronized Lymphoma Cells and Inhibition of Cell Division. Nature 226, 548–549 (1970). https://doi.org/10.1038/226548a0

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  • DOI: https://doi.org/10.1038/226548a0

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