Abstract
HEPATIC tyrosine transaminase activity in untreated rats1 or mice2 given free access to dietary protein3 and exposed to alternate periods of light and darkness4 undergoes four-fold variations during each 24 h period. Much of the amino-acid intake is metabolized by deamination5 and we have sought to determine whether the rate of transformation of injected tyrosine in the mouse varies with time of day.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wurtman, R. J., and Axelrod, J., Proc. US Nat. Acad. Sci., 57, 1594 (1967).
Rose, C. M., Chou, C., Zigmond, M. J., and Wurtman, R. J., Fed. Proc., 28, 690 (1969).
Wurtman, R. J., Shoemaker, W. J., and Larin, F., Proc. US Nat. Acad. Sci., 59, 800 (1968).
Zigmond, M. J., Shoemaker, W. J., Larin, F., and Wurtman, R. J., J. Nutrit., 98, 71 (1969).
Elwyn, D. H., in Mammalian Protein Metabolism (edit. by Munro, H. M.), 4 (Academic press, New York, in the Press).
Waalkes, T. P., and Udenfriend, S., J. Lab. Clin. Med., 50, 733 (1957).
Wurtman, R. J., in Mammalian Protein Metabolism (edit. by Munro, H. N.), 4 (Academic Press, New York, in the press).
Coburn, S. P., Seidenberg, M., and Fuller, R. W., Proc. Soc. Exp. Biol. Med., 129, 338 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROSE, C., WURTMAN, R. Daily Rhythms in Content and Utilization of Tyrosine in the Whole Mouse. Nature 226, 454–455 (1970). https://doi.org/10.1038/226454a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/226454a0
This article is cited by
-
Cold exposure: Effects on hepatic tryptophan oxygenase and tyrosine aminotransferase, plasma tryptophan and tyrosine, and brain monoamines
Experientia (1974)
-
Orientierende Untersuchung des zirkadianen Plasma-Tyrosin-Rhythmus depressiver Syndrome unterschiedlicher �tiologie
Archiv f�r Psychiatrie und Nervenkrankheiten (1972)
-
Effects of sleep deprivation on the periodicity of tyrosine metabolism in mice
Experientia (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.