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Inability of Plasma from Patients with Neoplasia to support Macrophage Recognition of Foreignness

Nature volume 226, pages 1049–1050 (1970)Cite this article

Abstract

THE involvement of the reticuloendothelial system (RES) in various disease processes is well documented, but the role of phagocytic promoting factors, or opsonins1–4, is still not clear. Opsonic depletion in animals—the so-called “blockade”5–8—has been shown to be associated with decreased immunogenicity9–11 and impaired resistance to infection12,13. Because tumour cells which possess tumour-specific antigens14 are, effectively, “non-self” it is possible that serum opsonic depletion might occur in the neoplastic patient. Phagocytic alterations have been found in patients with neoplasia15–18, but it is not known if these are attributable to a macrophage alteration or an opsonic defect.

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Authors and Affiliations

  1. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, 70112

    J. C. PISANO, N. R. DI LUZIO & N. K. SALKY

  2. Departments of Physiology and Biophysics and Medicine, University of Tennessee Medical Units, Memphis, Tennessee, 38103

    J. C. PISANO, N. R. DI LUZIO & N. K. SALKY

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  1. J. C. PISANO
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  2. N. R. DI LUZIO
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  3. N. K. SALKY
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PISANO, J., DI LUZIO, N. & SALKY, N. Inability of Plasma from Patients with Neoplasia to support Macrophage Recognition of Foreignness. Nature 226, 1049–1050 (1970). https://doi.org/10.1038/2261049a0

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