Abstract
STANLEY et al. reported the production of a lymphoma (2731/L) in Prince Henry (PH) mice after inoculation with spleen cells from a PH mouse with chronic (272 days) reovirus type 3 infection1. They suggested a relationship between reoviruses and the tumour. From recent data on the prevalence of murine leukaemia virus in most mouse strains2, we would conclude that lymphomas induced in mice can, with considerable certainty, be attributed to murine leukaemia (C-type RNA) viruses in the passage materials. We have therefore tested for the presence of a murine leukaemia virus in the 2731/L tumour as well as other mouse lymphomas developing after various procedures (Table 1) in Stanley's PH line.
Access options
Subscribe to Journal
Get full journal access for 1 year
$199.00
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1
Stanley, N. F., Walters, M. N-I., Leak, P. J., and Keast, D., Proc. Soc. Exp. Biol. and Med., 121, 90 (1966).
- 2
Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).
- 3
Duc-Nugent, H., J. Virol., 2, 643 (1968).
- 4
Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., Proc. US Nat. Acad. Sci., 53, 931 (1965).
- 5
Hartley, J. W., and Rowe, W. P., Proc. US Nat. Acad. Sci., 55, 780 (1966).
- 6
Keast, D., and Stanley, N. F., Proc. Soc. Exp. Biol. and Med., 122, 1091 (1966).
- 7
Schwartz, R. S., and Beldotti, L., Science, 149, 1511 (1965).
- 8
Turner, W., Chirigos, M. A., and Scott, D., Cancer Res., 28, 1064 (1968).
- 9
Levy, J. A., Henle, G., Henle, W., and Zajac, B. A., Nature, 220, 607 (1968).
- 10
Stanley, N. F., and Keast, D., Austral. J. Exp. Biol. Med. Sci., 45, 517 (1967).
Author information
Affiliations
Rights and permissions
About this article
Cite this article
LEVY, J., HUEBNER, R. Association of Murine Leukaemia Virus from a Mouse Lymphoma (2731/L) with Reovirus Type 3 Infection. Nature 225, 949–950 (1970). https://doi.org/10.1038/225949a0
Received:
Issue Date:
Further reading
-
A Role for RNA Viruses in the Pathogenesis of Burkitt's Lymphoma: The Need for Reappraisal
Advances in Hematology (2012)
-
Leukemia induction in C3H mice following their inoculation with normal AKR lymphoid cells
International Journal of Cancer (1973)
-
Murine lymphoma induced by reovirus 3
Pathology (1971)
-
IMMUNOSURVEILLANCE AND CANCER
The Lancet (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
