Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Rare Bases in Animal DNA

Abstract

THE rare bases which occur in animal DNA deserve special attention because their presence is directly relevant to questions concerning the cellular, subcellular and species specificity of DNA methylation. In animal DNA, the base 5-methylcytosine (5-MeCyt) is usually detected1,2. Numerous attempts to find N6-methyladenine (6-MeAde)—which is characteristic of the DNA of various microorganisms3–5—in animal DNA proved unsuccessful3,6–9. This may be accounted for by the fact that animal cells do not contain the enzymes required for methylating DNA at adenine residues7–9. Nevertheless, 6-MeAde and certain N2-methylated derivatives of guanine have been recently discovered in appreciable amounts in bovine and human sperm DNA10. Our present knowledge on the specificity of DNA methylation in animal cells is not only scanty but also contradictory.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Wyatt, G. R., Biochem. J., 48, 584 (1951).

    CAS  Article  Google Scholar 

  2. Antonov, A. S., Favorova, O. O., and Belozersky, A. N., Dokl. Akad. Nauk SSSR, 147, 1480 (1962).

    CAS  Google Scholar 

  3. Dunn, D. B., and Smith, J. D., Biochem. J., 68, 627 (1958).

    CAS  Article  Google Scholar 

  4. Vanyushin, B. F., Belozersky, A. N., Kokurina, N. A., and Kadirova, D. X., Nature, 218, 1066 (1968).

    ADS  CAS  Article  Google Scholar 

  5. Pakhomova, M. V., Zaitseva, G. N., and Belozersky, A. N., Dokl. Akad. Nauk SSSR, 182, 712 (1968).

    CAS  Google Scholar 

  6. Brown, G. M., and Attardi, G., Biochem. Biophys. Res. Commun., 20, 298 (1965).

    CAS  Article  Google Scholar 

  7. Sheid, B., Srinivasan, P. R., and Borek, E., Biochemistry, 7, 280 (1968).

    CAS  Article  Google Scholar 

  8. Kalousek, F., and Morris, N. R., J. Biol. Chem., 244, 1157 (1969).

    CAS  Google Scholar 

  9. Grippo, P., Iaccarino, M., Parisi, E., and Scarano, E., J. Mol. Biol., 36, 195 (1968).

    CAS  Article  Google Scholar 

  10. Unger, G., and Venner, H., Z. Physiol. Chem., 344, 280 (1966).

    CAS  Article  Google Scholar 

  11. Marmur, J., J. Mol. Biol., 3, 208 (1961).

    CAS  Article  Google Scholar 

  12. Kirby, K. S., Biochim. Biophys. Acta, 36, 117 (1959).

    CAS  Article  Google Scholar 

  13. Vanyushin, B. F., and Belozersky, A. N., Dokl. Akad. Nauk SSSR, 129, 944 (1959).

    CAS  Google Scholar 

  14. Doscocil, J., and Sorm, F., Biochim. Biophys. Acta, 55, 953 (1962).

    Article  Google Scholar 

  15. Berdishev, G. D., Korotaev, G. K., Boyarskikh, G. V., and Vanyushin, B. F., Biokhimia, 32, 988 (1967).

    Google Scholar 

  16. Vanyushin, B. F., Korotaev, G. K., Mazin, A. L., and Berdishev, G. D., Biokhimia, 34, 201 (1969).

    Google Scholar 

  17. Mazin, A. L., Vanyushin, B. F., and Korotaev, G. K., Dokl. Akad. Nauk SSSR, 186, 1434 (1969).

    CAS  Google Scholar 

  18. Schwartz, M. N., Trautner, T. A., and Kornberg, A., J. Biol. Chem., 237, 1961 (1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

VANYUSHIN, B., TKACHEVA, S. & BELOZERSKY, A. Rare Bases in Animal DNA. Nature 225, 948–949 (1970). https://doi.org/10.1038/225948a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/225948a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing