Abstract
FROM the site of an Arthus reaction or burn lesion, a chemical factor has been isolated (“leucoegressin”) that causes the accumulation of polymorphonuclear leucocytes1,2. A possible precursor has, moreover, been located in the γ2-globulin fraction of normal rabbit serum3, because when six protein fractions such as albumin and α1, α2, β1, β2 (or γ1) and γ2-globulin fractions—obtained from normal rabbit serum by block electrophoresis on a ‘Pevikon C-870’ column—were each incubated with a purified SH-dependent protease4,5 from inflammatory tissue, the γ2-globulin fraction became strongly chemotactic for polymorphonuclear leucocytes. We now are able to report further information on its precursor. We have evidence that immunoglobulin G (IgG) gives rise to a chemotactic factor during these inflammatory processes, and it seems that the chemotactic factor has antigenic sites in common with IgG and can in fact be generated by the enzymatic treatment of fractionated IgG in vitro.
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YOSHINAGA, M., MAYUMI, M., YAMAMOTO, S. et al. Immunoglobulin G as Possible Precursor of Chemotactic Factor. Nature 225, 1138–1139 (1970). https://doi.org/10.1038/2251138a0
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DOI: https://doi.org/10.1038/2251138a0
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