Alcohol-induced Malabsorption of Vitamin B12 in Man

Abstract

INTOXICATION with alcohol is frequently associated with diarrhoea, and disturbances of intestinal function have been reported to be common in chronic alcoholics studied shortly after drinking-bouts1–5. Because the normal diet of alcoholics is characteristically poor, it is not clear whether the transient malabsorption frequently found can be attributed to a direct toxic effect of ethanol on the small intestine, or to a nutritional deficiency. We therefore studied the effects of the experimental ingestion of ethanol in man on vitamin B12 absorption under controlled metabolic ward conditions in the absence of nutritional deficiency.

References

  1. 1

    Roggin, G. M., Kater, R. M. H., Tobon, F., and Iber, F. L., Ann. Int. Med., 70, 1070 (1969).

    Article  Google Scholar 

  2. 2

    Small, M., Longarini, A., and Zamcheck, N., Amer. J. Med., 27, 575 (1959).

    CAS  Article  Google Scholar 

  3. 3

    Halstead, C. H., Griggs, R. C., and Harris, J. W., J. Lab. Clin. Med., 69, 116 (1967).

    Google Scholar 

  4. 4

    Tomasulo, P. A., Kater, R. M. H., and Iber, F. L., Amer. J. Clin. Nutr., 21, 1340 (1968).

    Article  Google Scholar 

  5. 5

    Thomson, A., Baker, H., and Leevy, C. M., Amer. J. Clin. Nutr., 21, 537 (1968).

    Google Scholar 

  6. 6

    Lieber, C. S., and Rubin, E., Amer. J. Med., 44, 200 (1968).

    CAS  Article  Google Scholar 

  7. 7

    Lindenbaum, J., and Lieber, C. S., New Engl. J. Med., 281, 333 (1969).

    CAS  Article  Google Scholar 

  8. 8

    Schilling, R. F., J. Lab. Clin. Med., 42, 869 (1953).

    Google Scholar 

  9. 9

    Lau, K., Gottlieb, C., Wasserman, L. R., and Herbert, V., Blood, 26, 202 (1965).

    CAS  Article  Google Scholar 

  10. 10

    Curzon, G., and Walsh, J., Clin. Chim. Acta, 7, 657 (1962).

    CAS  Article  Google Scholar 

  11. 11

    Chang, T., Lewis, J., and Glazko, A. J., Biochim. Biophys. Acta, 135, 1000 (1967).

    CAS  Article  Google Scholar 

  12. 12

    Israel, U., Salazar, I., and Rosenmann, E., J. Nutrit., 96, 499 (1968).

    CAS  PubMed  Google Scholar 

Download references

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LINDENBAUM, J., LIEBER, C. Alcohol-induced Malabsorption of Vitamin B12 in Man. Nature 224, 806 (1969). https://doi.org/10.1038/224806a0

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