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Neutralization of Graffi Leukaemia Virus


GRAFFI leukaemia virus (GiLV) can be neutralized by specific antisera prepared either in rabbit1 or in mice2, but very little is known about the antigenic relations between GiLV and the other murine leukaemia viruses. Graffi et al. reported that an anti-AKR strain leukaemia rabbit anti-serum can neutralize GiLV3, while Steeves et al. observed that ariti-GiLV mice antisera are inefficient against Friend and Rauscher viruses4. The latter result contrasts with the existence of a cross-reacting “FMRGi” antigen at the membrane of leukaemic cells induced by Friend, Moloney, Rauscher and Graffi viruses5,6. Studies on the neutralization of GiLV reported here indicate that the antigens revealed by virus neutralization are different from FMRGi cellular antigen, and that an antigenic specificity of GiLV neutralization can be detected only by mice antisera. On the contrary, rabbit and rat antisera show a cross-reactivity between Gross, Graffi, Moloney and probably the other murine leukaemia viruses.

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LEVY, J., VARET, B., OPPENHEIM, E. et al. Neutralization of Graffi Leukaemia Virus. Nature 224, 606–608 (1969).

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