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Neutralization of Graffi Leukaemia Virus

Abstract

GRAFFI leukaemia virus (GiLV) can be neutralized by specific antisera prepared either in rabbit1 or in mice2, but very little is known about the antigenic relations between GiLV and the other murine leukaemia viruses. Graffi et al. reported that an anti-AKR strain leukaemia rabbit anti-serum can neutralize GiLV3, while Steeves et al. observed that ariti-GiLV mice antisera are inefficient against Friend and Rauscher viruses4. The latter result contrasts with the existence of a cross-reacting “FMRGi” antigen at the membrane of leukaemic cells induced by Friend, Moloney, Rauscher and Graffi viruses5,6. Studies on the neutralization of GiLV reported here indicate that the antigens revealed by virus neutralization are different from FMRGi cellular antigen, and that an antigenic specificity of GiLV neutralization can be detected only by mice antisera. On the contrary, rabbit and rat antisera show a cross-reactivity between Gross, Graffi, Moloney and probably the other murine leukaemia viruses.

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References

  1. 1

    Graffi, A., Fey, F., Hoffmann, F., and Krischke, W., Klin. Wschr., 35, 465 (1957).

    CAS  Article  Google Scholar 

  2. 2

    Pasternak, G., J. Nat. Cancer Inst., 16, 71 (1965).

    Article  Google Scholar 

  3. 3

    Pasternak, G., and Graffi, A., Z. Naturf., 16, 73 (1961).

    Article  Google Scholar 

  4. 4

    Steeves, R. A., and Axelrad, A., Int. J. Cancer, 2, 235 (1967).

    CAS  Article  Google Scholar 

  5. 5

    Levy, J. P., Leclere, J. C., Varet, B., Oppenheim, S., and Silvestre, D., Nouv. Rev. Fr. Hémato, 7, 705 (1967).

    CAS  Google Scholar 

  6. 6

    Levy, J. P., Leclere, J. C., Varet, B., and Oppenheim, S., J. Nat. Cancer Inst., 41, 743 (1968).

    CAS  PubMed  Google Scholar 

  7. 7

    Chenaille, P., Levy, J. P., Tavitian, A., and Boiron, M., Nature, 213, 107 (1963).

    ADS  Article  Google Scholar 

  8. 8

    Huebner, R. J., Hartley, J. W., Turner, M. C., and Lane, W. T., Proc. US Nat. Acad. Sci., 50, 379 (1963).

    CAS  ADS  Article  Google Scholar 

  9. 9

    Oppenheim, S., Levy, J. P., and Leclerc, J. C., CR Acad. Sci. Paris, 268, 620 (1969).

    CAS  Google Scholar 

  10. 10

    Huebner, R. J., Proc. US Nat. Acad. Sci., 58, 835 (1967).

    CAS  ADS  Article  Google Scholar 

  11. 11

    Igel, H., Huebner, R. J., Deppa, B., and Bumgarner, S., Proc. US Nat. Acad. Sci., 58, 1870 (1967).

    CAS  ADS  Article  Google Scholar 

  12. 12

    O'Connor, T. E., and Fischinger, P. T., Science, 159, 325 (1968).

    CAS  ADS  Article  Google Scholar 

  13. 13

    Fefer, A., Mc'Coy, J. L., and Glynn, P., Cancer Res., 27, 1626 (1967).

    CAS  PubMed  Google Scholar 

  14. 14

    Leclere, J. C., Levy, J. P., Varet, B., and Oppenheim, S., CR Acad. Sci., 266, 2606 (1968).

    Google Scholar 

  15. 15

    Sarma, P. S., Cheong, M. P., Hartley, J. W., and Huebner, R. J., Virology, 38, 180 (1967).

    Article  Google Scholar 

  16. 16

    Old, L. J., Geering, G., and Oetigen, H. F., Cancer Res., 28 1288 (1968).

    CAS  PubMed  Google Scholar 

  17. 17

    Wahren, B., Cancer Res., 24, 411 (1963).

    Google Scholar 

  18. 18

    Klein, E., and Klein, G., Science, 145, 1316 (1964).

    CAS  ADS  Article  Google Scholar 

  19. 19

    Pasternak, L., and Pasternak, G., Arch. Ges. Forsch., 32, 301 (1968).

    CAS  Google Scholar 

  20. 20

    Steeves, R. A., Cancer Res., 28, 3381 (1968).

    Google Scholar 

  21. 21

    Wahren, B., thesis, Karolinska Institutet (1966).

  22. 22

    Geering, G., Old, L. J., and Boyse, E. A., J. Exp. Med., 124, 753 (1966).

    CAS  Article  Google Scholar 

  23. 23

    Mc'Coy, J. L., Fefer, A., and Glynn, J. P., Cancer Res., 28, 942 (1968).

    CAS  Google Scholar 

  24. 24

    Gross, L., Proc. Soc. Exp. Biol. and Med., 119, 420 (1965).

    CAS  Article  Google Scholar 

  25. 25

    Gross, L., Proc. Third Symp. Comp. Leukemia Res. Bibl. Med., 31 (Karger, Basel, NY, 1968).

  26. 26

    Pasternak, G., and Graffi, A., Z. Naturforsch., 16, 73 (1961).

    Article  Google Scholar 

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LEVY, J., VARET, B., OPPENHEIM, E. et al. Neutralization of Graffi Leukaemia Virus. Nature 224, 606–608 (1969). https://doi.org/10.1038/224606a0

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