Abstract
GRAFFI leukaemia virus (GiLV) can be neutralized by specific antisera prepared either in rabbit1 or in mice2, but very little is known about the antigenic relations between GiLV and the other murine leukaemia viruses. Graffi et al. reported that an anti-AKR strain leukaemia rabbit anti-serum can neutralize GiLV3, while Steeves et al. observed that ariti-GiLV mice antisera are inefficient against Friend and Rauscher viruses4. The latter result contrasts with the existence of a cross-reacting “FMRGi” antigen at the membrane of leukaemic cells induced by Friend, Moloney, Rauscher and Graffi viruses5,6. Studies on the neutralization of GiLV reported here indicate that the antigens revealed by virus neutralization are different from FMRGi cellular antigen, and that an antigenic specificity of GiLV neutralization can be detected only by mice antisera. On the contrary, rabbit and rat antisera show a cross-reactivity between Gross, Graffi, Moloney and probably the other murine leukaemia viruses.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Graffi, A., Fey, F., Hoffmann, F., and Krischke, W., Klin. Wschr., 35, 465 (1957).
Pasternak, G., J. Nat. Cancer Inst., 16, 71 (1965).
Pasternak, G., and Graffi, A., Z. Naturf., 16, 73 (1961).
Steeves, R. A., and Axelrad, A., Int. J. Cancer, 2, 235 (1967).
Levy, J. P., Leclere, J. C., Varet, B., Oppenheim, S., and Silvestre, D., Nouv. Rev. Fr. Hémato, 7, 705 (1967).
Levy, J. P., Leclere, J. C., Varet, B., and Oppenheim, S., J. Nat. Cancer Inst., 41, 743 (1968).
Chenaille, P., Levy, J. P., Tavitian, A., and Boiron, M., Nature, 213, 107 (1963).
Huebner, R. J., Hartley, J. W., Turner, M. C., and Lane, W. T., Proc. US Nat. Acad. Sci., 50, 379 (1963).
Oppenheim, S., Levy, J. P., and Leclerc, J. C., CR Acad. Sci. Paris, 268, 620 (1969).
Huebner, R. J., Proc. US Nat. Acad. Sci., 58, 835 (1967).
Igel, H., Huebner, R. J., Deppa, B., and Bumgarner, S., Proc. US Nat. Acad. Sci., 58, 1870 (1967).
O'Connor, T. E., and Fischinger, P. T., Science, 159, 325 (1968).
Fefer, A., Mc'Coy, J. L., and Glynn, P., Cancer Res., 27, 1626 (1967).
Leclere, J. C., Levy, J. P., Varet, B., and Oppenheim, S., CR Acad. Sci., 266, 2606 (1968).
Sarma, P. S., Cheong, M. P., Hartley, J. W., and Huebner, R. J., Virology, 38, 180 (1967).
Old, L. J., Geering, G., and Oetigen, H. F., Cancer Res., 28 1288 (1968).
Wahren, B., Cancer Res., 24, 411 (1963).
Klein, E., and Klein, G., Science, 145, 1316 (1964).
Pasternak, L., and Pasternak, G., Arch. Ges. Forsch., 32, 301 (1968).
Steeves, R. A., Cancer Res., 28, 3381 (1968).
Wahren, B., thesis, Karolinska Institutet (1966).
Geering, G., Old, L. J., and Boyse, E. A., J. Exp. Med., 124, 753 (1966).
Mc'Coy, J. L., Fefer, A., and Glynn, J. P., Cancer Res., 28, 942 (1968).
Gross, L., Proc. Soc. Exp. Biol. and Med., 119, 420 (1965).
Gross, L., Proc. Third Symp. Comp. Leukemia Res. Bibl. Med., 31 (Karger, Basel, NY, 1968).
Pasternak, G., and Graffi, A., Z. Naturforsch., 16, 73 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LEVY, J., VARET, B., OPPENHEIM, E. et al. Neutralization of Graffi Leukaemia Virus. Nature 224, 606–608 (1969). https://doi.org/10.1038/224606a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/224606a0
This article is cited by
-
Defective Friend Spleen Focus-forming Virus: Pseudotype Neutralization by Helper-specific Antisera
Nature New Biology (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
