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Conformation of the Free and Antigen-bound IgM Antibody Molecules

Abstract

THE two major classes of antibody molecule, IgG and IgM1, have molecular weights of 150,000 and 900,000, respectively. They are composed of heavy and light polypeptide chains. In IgM each heavy (μ) chain, molecular weight 70,000, is linked by a disulphide bridge to a light (L) chain, molecular weight 23,000, and is probably linked by three further bridges to other μ chains2–10.

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FEINSTEIN, A., MUNN, E. Conformation of the Free and Antigen-bound IgM Antibody Molecules. Nature 224, 1307–1309 (1969). https://doi.org/10.1038/2241307a0

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