Insulin Secretion in Sheep with Autotransplants of the Pancreas


THE adrenal gland1,2, the ovary3,4 and the thyroid gland5 have been transplanted to the exteriorized carotid artery–jugular vein loop in the neck of the merino sheep, where it is readily accessible for physiological studies. Recently, successful transplantation of a portion of the pancreas to a similar neck loop in the merino sheep has been achieved6. The blood supply to the pancreas in sheep is such that the tail of the pancreas is supplied by a single branch of the splenic artery, and the venous drainage is by way of the splenic vein. By sacrificing the spleen, this part of the pancreas can be resected with its blood supply intact and transplanted to a vascular anastomosis with the vessels in the neck. To reduce the secretion of the exocrine pancreas, the pancreatic duct was ligated 2 or 3 months before the pancreatic transplantation.

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BEAVEN, D., SALAMONSEN, L., HART, D. et al. Insulin Secretion in Sheep with Autotransplants of the Pancreas. Nature 223, 955 (1969).

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