Tissue-specific Inhibition of Lung Alveolar Cell Mitosis in Organ Culture


THE existence of a growth-regulating system has now been established in several tissues, but has been thoroughly investigated only in mammalian epidermis1–3 and granulocytes4. Essential components in this controlling mechanism have been found to be chemical messengers, known as chalones, produced by cells which themselves form the target tissue. As a result of chalone activity, the mitotic cycle of the cell is modified and the rate of growth of the whole tissue potentially depressed5. It is not yet known, however, whether the growth-regulating chalone is a feature common to all tissues.

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SIMNETT, J., FISHER, J. & HEPPLESTON, A. Tissue-specific Inhibition of Lung Alveolar Cell Mitosis in Organ Culture. Nature 223, 944–946 (1969). https://doi.org/10.1038/223944a0

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