Conformation of Cholinergic Molecules relevant to Acetylcholinesterase

Abstract

Crystal structure analyses of several cholinergic molecules, combined with their relative rates of hydrolysis by acetylcholinesterase, allow one to determine the conformation of labile cholinergic molecules relevant to their interaction with the enzyme.

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CHOTHIA, C., PAULING, P. Conformation of Cholinergic Molecules relevant to Acetylcholinesterase. Nature 223, 919–921 (1969). https://doi.org/10.1038/223919a0

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