Abstract
Crystal structure analyses of several cholinergic molecules, combined with their relative rates of hydrolysis by acetylcholinesterase, allow one to determine the conformation of labile cholinergic molecules relevant to their interaction with the enzyme.
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References
Beckett, A. H., Harper, N. J., and Clitherow, J. W., J. Pharm. Pharmacol., 15, 362 (1963).
Scott, K. A., and Mautner, H. G., Biochem. Pharmacol., 13, 907 (1964).
Chothia, C. H., and Pauling, P. J., Chem. Commun., 30, 746 (1969).
Klyne, W., and Prelog, V., Experientia, 12, 521 (1960).
Chothia, C. H., and Pauling, P. J., Nature, 219, 1156 (1968).
Sundaralingham, M., Nature, 217, 35 (1968).
Chothia, C. H., and Pauling, P. J., Chem. Commun., 30, 626 (1969).
Pauling, P. J., in Structural Chemistry and Molecular Biology (edit. by Rich, A. and Davidson, N.), 555 (W. H. Freeman and Co. San Francisco, 1968).
Shefter, E., Mautner, H. G., and Smissman, E. E., Abstracts of Eighth International Congress of Crystallography, Acta Cryst., A, 25, S201 (1969).
Shefter, E., and Kennard, O., Science, 153, 1389 (1966).
Canepa, F. G., Pauling, P. J., and Sörum, H., Nature, 210, 907 (1966).
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CHOTHIA, C., PAULING, P. Conformation of Cholinergic Molecules relevant to Acetylcholinesterase. Nature 223, 919–921 (1969). https://doi.org/10.1038/223919a0
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DOI: https://doi.org/10.1038/223919a0
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