Abstract
Lowering the temperature of E. coli to 8° C results in an accumulation of ribosomal subunits arising from a block in initiating protein synthesis. It is likely that this explains the fact that cell division in E. coli does not occur at temperatures below 8° C.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nakada, D., and Kaji, A., Proc. US Nat. Acad. Sci., 57, 128 (1967); Nomura, M., Lowry, C. V., and Guthrie, C., ibid., 58, 1487 (1967); Eisenstadt, J. M., and Brawerman, G., ibid., 58, 1560 (1967); Hille, M. B., Miller, M. J., Iwasaki, K., and Wahba, A. J., ibid., 58, 1652 (1967); Ghosh, H. P., and Khorana, H. G., ibid., 58, 2455 (1967); Mukundun, M. A., Hershey, J. W. B., Dewey, K. F., and Thatch, R. E., Nature, 217, 1013 (1968); Guthrie, C., and Nomura, M., ibid., 219, 232 (1968).
Kaempfer, R. O. R., Meselson, M., and Raskas, H. J., J. Mol. Biol., 31, 277 (1968).
Das, H. K., and Goldstein, A., J. Mol. Biol., 31, 209 (1968).
Godson, G. N., and Sinsheimer, R. L., Biochim. Biophys. Acta, 149, 489 (1967).
Davis, B. D., and Mingioli, E. S., J. Bact., 60, 17 (1950).
Schleif, R. F., J. Mol. Biol., 37, 119 (1968).
Green, M. H., and Hall, B. D., Biophys. J., 1, 517 (1961).
Peacock, A. C., and Dingman, C. W., Biochemistry, 6, 1818 (1967).
Schlessinger, D., Mangiarotti, G., and Apirion, D., Proc. US Nat. Acad. Sci., 58, 1782 (1967).
Igarashi, S., and Paranchych, W., Biochemistry, 6, 2571 (1967).
Ingraham, J. L., J. Bact., 76, 75 (1958).
Kohler, R. E., Ron, E. Z., and Davis, B. D., J. Mol. Biol., 36, 71 (1968); Phillips, L. A., Hotham-Iglewski, B., and Franklin, R. M., ibid., 40, 279 (1969).
Flessel, C. P., Ralph, P., and Rich, A., Science, 158, 658 (1967).
Goldstein, A., Goldstein, D. B., and Lowney, L. I., J. Mol. Biol., 9, 213 (1964).
Marcker, K., and Sanger, F., J. Mol. Biol., 8, 835 (1964).
McCormick, W., and Penman, S., J. Mol. Biol., 39, 315 (1969).
Hartwell, L. H., and McLaughlin, C. S., Proc. US Nat. Acad. Sci., 62, 468 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FRIEDMAN, H., LU, P. & RICH, A. Ribosomal Subunits produced by Cold Sensitive Initiation of Protein Synthesis. Nature 223, 909–913 (1969). https://doi.org/10.1038/223909a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/223909a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
