IN recent years evidence has accumulated that part of the membrane potential of some cells can be due to the activity of an electrogenic sodium pump1–7. This pump can have its activity increased by neurochemical transmitters8–12 or decreased by light stimulating a photo-receptor13. This communication describes the responses of two identified neurones in the right parietal ganglia of the snail Helix aspersa. Both cells are hyperpolarized by acetylcholine (ACh). In Type I the action of ACh is to increase the membrane permeability to chloride ions and so bring the membrane potential towards EC1. In the other cell (Type II) the effect of ACh is slowly to increase the membrane permeability to sodium ions, and the increased sodium concentration of the neurone stimulates the electrogenic sodium pump and so hyperpolarizes the cell.
Subscribe to Journal
Get full journal access for 1 year
only $3.83 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Born, G. V. R., and Bulbring, E., J. Physiol., 131, 690 (1956).
Kernan, R. P., J. Physiol., 162, 129 (1962).
Ritchie, J. M., and Straub, R. W., J. Physiol., 136, 80 (1957).
Connelly, C. M., Rev. Mod. Physics, 31, 475 (1959).
Kerkut, G. A., and Thomas, R. C., Comp. Biochem. Physiol., 14, 167 (1965).
Carpenter, D. O., and Alving, B. O., J. Gen. Physiol., 52, 1 (1968).
Thomas, R. C., J. Physiol., 201, 495 (1969).
Burnstock, G., J. Physiol., 143, 183 (1958).
Nishi, S., and Koketsu, K., J. Neurophysiol., 31, 717 (1968).
Ascher, P., J. Physiol., 198, 48P (1968).
Kerkut, G. A., Brown, L. C., and Walker, R. J., Life Sci., 8, i, 297 (1969).
Pinsker, H., and Kandel, E., Science, 163, 931 (1969).
Smith, T. G., and Stell, W. K., Science, 162, 456 (1968).
Eccles, J. C., The Physiology of Synapses (Springer, Berlin, 1963).
Kerkut, G. A., and York, B., Comp. Biochem. Physiol., 28, 1125 (1969).
About this article
Cite this article
KERKUT, G., BROWN, L. & WALKER, R. Cholinergic IPSP by Stimulation of the Electrogenic Sodium Pump. Nature 223, 864–865 (1969). https://doi.org/10.1038/223864a0
General Pharmacology: The Vascular System (1999)
Bursting firing of action potentials in central snail neurons elicited by d-amphetamine: role of the electrogenic sodium pump
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology (1995)
Studying the isolated central nervous system; A report on 35 years: More inquisitive than acquisitive
Comparative Biochemistry and Physiology Part A: Physiology (1989)
On the membrane potential independent mechanism of the sodium pump-induced inhibition of spontaneous electrical activity of japanese land snail neurons
Comparative Biochemistry and Physiology Part A: Physiology (1984)