Chromosome Changes in Human Cells induced by Herpes Simplex, Types 1 and 2

Abstract

HERPES simplex virus (HSV) is of interest both as a common infectious agent and because of its putative role (type 2 virus) in carcinoma of the cervix1,2. The type 1 virus induces chromosome damage in both established and primary cell cultures of the Chinese hamster3–5, in cultured Syrian hamster cells6 and in cultured monkey kidney cells7. In human leucocytes Aya et al.8 have described HSV induced breaks, while Stich et al.5 described more extreme effects, including fragmentation, in human embryonic lung cells. But neither damage by HSV type 2 nor the full range of effects in human cells induced by either types 1 or 2 has been described. Here we describe various chromosome abnormalities produced by both forms of HSV, and point out similarities between some of these abnormalities and those which occur in human cancers, in permanent human leucocyte cell lines, and in human fibroblasts transformed by SV40.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Josey, W. E., Nahmias, A. J., and Naib, Z. M., Amer. J. Obstet. Gynec., 101, 718 (1968).

  2. 2

    Rawls, W. E., Tompkins, W. A. F., Figueroa, M. W., and Melnick, J. L., Science, 161, 1255 (1968).

  3. 3

    Hampar, B., and Ellison, S. A., Nature, 192, 145 (1961).

  4. 4

    Mazzone, H. M., and Yerganian, G., Exp. Cell Res., 30, 591 (1963).

  5. 5

    Stich, H. F., Hsu, T. C., and Rapp, F., Virology, 22, 439 (1964).

  6. 6

    Waubke, R., zur Hausen, H., and Henle, W., J. Virology, 2, 1047 (1968).

  7. 7

    Boiron, M., Tanzer, J., Thomas, M., and Hampe, A., Nature, 209, 737 (1966).

  8. 8

    Aya, T., Makino, S., and Yamada, M., Proc. Japan Acad., 43, 239 (1967).

  9. 9

    Reed, L. J., and Muench, H., Amer. J. Hyg., 27, 493 (1938).

  10. 10

    Miles, C. P., and O'Neill, F., Cytogenetics, 5, 321 (1966).

  11. 11

    Ferguson-Smith, M. A., Ferguson-Smith, M. E., Ellis, P. M., and Dickson, M., Cytogenetics, 1, 325 (1962).

  12. 12

    Miles, C. P., O'Neill, F., Armstrong, D., Clarkson, B., and Keane, J., Cancer Res., 28, 481 (1968).

  13. 13

    Cohen, M. M., and Shaw, M. W., J. Cell Biol., 23, 386 (1964).

  14. 14

    Kaback, M. M., Saksela, E., and Mellman, W. J., Exp. Cell Res., 34, 182 (1964).

  15. 15

    Moorhead, P. S., and Saksela, E., J. Cell. Comp. Physiol., 62, 57 (1963).

  16. 16

    Wolman, S. R., Hirschhorn, K., and Todaro, G. J., Cytogenetics, 3, 57 (1964).

  17. 17

    zur Hausen, H., J. Nat. Cancer Inst., 38, 683 (1967).

  18. 18

    Miles, C. P., Geller, W., and O'Neill, F., Cancer, 19, 1103 (1966).

  19. 19

    Miles, C. P., Cancer, 20, 1253 (1967).

  20. 20

    Spiers, A. S. D., and Baikie, A. G., Brit. J. Cancer, 21, 679 (1968).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

O'NEILL, F., MILES, C. Chromosome Changes in Human Cells induced by Herpes Simplex, Types 1 and 2. Nature 223, 851–852 (1969). https://doi.org/10.1038/223851a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.