Effect of 3,4-Benzo(a)pyrene on Mouse Lung Primordia in vitro

Abstract

ORGAN cultures of mammalian lung primordium can acquire essentially all the adult cellular elements together with their chemical characteristics1–6. Several chemical carcinogens have been shown to induce neoplastic development in mouse lungs in vivo7. Here we show that 3,4-benzo(a)pyrene interferes with the normal development and differentiation of foetal mouse lung buds in vitro.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Aydelotte, M. B., in Cells and Tissues in Cultures (edit. by Willmer, E. N.), 2, (Academic Press, London, 1965).

  2. 2

    Chen, J. M., Exp. Cell Res., 7, 518 (1954).

  3. 3

    Chesterman, F. C., and Franks, L. M., J. Path. Bact., 79, 123 (1960).

  4. 4

    Sorokin, S. P., Develop. Biol., 3, 60 (1961).

  5. 5

    Sorokin, S. P., in Organogenesis (edit. by Dehann, R. L. and Ursprung, H.), 467 (Holt, Rinehart and Winston, New York, 1965).

  6. 6

    Waddell, W. R., Arch. Pathol., 47, 227 (1949).

  7. 7

    Kuschner, M., Amer. Rev. Resp. Disease, 98, 573 (1968).

  8. 8

    Alescio, T., and Colombo-Piperno, E., J. Embryol. Exp. Morphol., 17, 213 (1967).

  9. 9

    Taderera, J. V., Develop. Biol., 16, 489 (1967).

  10. 10

    Lasnitzki, I., Brit. J. Cancer, 10, 510 (1956).

  11. 11

    Laws, J., and Flaks, A., Brit. J. Cancer, 20, 550 (1966).

  12. 12

    Flaks, A., and Laws, J. O., Brit. J. Cancer, 22, 839 (1968).

  13. 13

    Markert, C., Cancer Res., 28, 1908 (1968).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

CHAN, P., SANDERS, F. & WYNDER, E. Effect of 3,4-Benzo(a)pyrene on Mouse Lung Primordia in vitro. Nature 223, 847–848 (1969). https://doi.org/10.1038/223847a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.